Calcitonin gene-related peptide (CGRP)-enhanced non-adrenergic non-cholinergic contraction of guinea-pig proximal colon
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چکیده
منابع مشابه
Calcitonin gene-related peptide inhibits nonadrenergic noncholinergic contraction of guinea pig distal colon.
In the guinea pig distal colon, calcitonin gene-related peptide (CGRP, 0.1-30 nM) produced a concentration-dependent inhibition in electrically-evoked nonadrenergic noncholinergic (NANC) contractions and exogenous substance P-induced contractions. Both the inhibitory actions of CGRP were insensitive to human CGRP(8-37) (1-3 microM), a CGRP1 receptor antagonist. These results indicate that in th...
متن کاملCalcitonin Gene-Related Peptide (CGRP)
Calcitonin gene-related peptide (CGRP) is a 37 amino acid vasoactive neuropeptide that is widely distributed in central and peripheral nervous systems in mammals. CGRP was discovered in 1982 by molecular cloning of calcitonin (CT) gene. CGRP-specific mRNA appears to predominate in the hypothalamus while CT mRNA predominates in the thyroid. CGRP has an amphiphilic α-helical secondary structure i...
متن کاملDevelopment and potential of non-peptide antagonists for calcitonin-gene-related peptide (CGRP) receptors: evidence for CGRP receptor heterogeneity.
Calcitonin-gene-related peptide (CGRP) is a 37-amino-acid vasodilatory peptide, of which two isoforms, alpha CGRP and beta CGRP, have been described. The use of C-terminal fragments of CGRP peptide, such as human alpha CGRP-(8-37), has led to the pharmacological subdivision of CGRP receptors into CGRP-1 [high potency for binding of human alpha CGRP-(8-37)] and CGRP-2 (lower potency) receptors. ...
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To study the polarity of the efferent pathway of the myenteric plexus, recordings were made of the mechanical activity of the longitudinal muscle of isolated guinea-pig ileal segments upon stimulation with an electrical field around the myenteric plexus contained within strips of longitudinal muscle (LM-MP) continuous with each end of ileal segment. The amplitude of the contractile response to ...
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The effect of some endogenous components -endogenous opiates, cholecystokinin (CCK), vasoactive intestinal polypeptide (VIP) and somatostatin-as inhibitory or excitatory transmitters in the local nervous pathways involved in peristaltic responses was examined. The peristaltic reflex was studied using a modification of the Trendelenberg preparation. In each preparation, the luminal distens...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 1995
ISSN: 0007-1188
DOI: 10.1111/j.1476-5381.1995.tb15038.x